肝硬化患者在运动期间的肝-平板血流 - 一项试点研究
Stefanos Volianitis1, Niels H Secher2,3, Otto Clemmesen3,4
1Department of Physical Education, College of Education, Qatar University, Doha, Qatar.
Physiological reports
|September 25, 2024
概括
肝硬化患者由于动脉中乳酸和氨水平增加而经历运动不耐受,尽管维持了血糖. 运动期间肝功能和血流变化有助于这些代谢障碍.
科学领域:
- 运动生理学 运动生理学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肝硬化时肝细胞功能受损和肝血流变化可能会影响运动期间的基质代谢.
- 运动不耐受是肝硬化患者的常见投诉.
研究的目的:
- 为了研究肝硬化患者在增量运动期间的肝硬化基质和代谢物流.
- 了解运动强度,肝功能和肝硬化中代谢反应之间的关系.
主要方法:
- 八名肝硬化患者接受了轻度,中度和强度的增量循环测试.
- 使用绿色氨酸输液测量肝脏血流量.
- 对动脉和肝脏静脉血液样本进行了乳酸,氨,葡萄糖和氨基酸的分析.
主要成果:
- 随着运动强度的增加,肝脏血液流量显著下降.
- 动脉中的乳酸盐和氨水平大幅增加,达到与较高工作负载的健康人相当的水平.
- 尽管肝脏的葡萄糖输出增加,但乳酸和氨的积累增加.
- 乳酸和氨的肝脏吸收增加,但不足以防止系统积累.
结论:
- 肝硬化患者的运动导致肝脏血流减少和动脉乳酸和氨的显著积累.
- 这些代谢变化,即使在工作负载较低时也会发生,可能会导致该人群的运动不耐受.
- 维持高血糖是通过增加肝脏的葡萄糖生产来实现的,但不会防止乳酸和氨的积累.
相关概念视频
Hepatic Portal System
1.0K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
1.0K
Exercise and Cardiovascular Response
745
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
745
Hepatic Drug Excretion: Enterohepatic Cycling
1.2K
Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
1.2K
Blood Supply to the Digestive System
1.0K
Splanchnic circulation refers to the network of blood vessels that supply and drain blood from the abdominal organs involved in digestion, including the stomach, liver, pancreas, intestines, and spleen. This circulation delivers essential nutrients and oxygen while removing waste products from these organs.
Blood Supply to the Digestive System: The splanchnic circulation involves three main arteries: the celiac artery (also known as the celiac trunk) and the superior and inferior mesenteric...
Blood Supply to the Digestive System: The splanchnic circulation involves three main arteries: the celiac artery (also known as the celiac trunk) and the superior and inferior mesenteric...
1.0K
Ultrasound II: Endoscopic Ultrasound and FibroScan
82
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
82
Liver Physiology
454
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
454


