一个无线,无电池的装置用于膀收缩的电神经调节
Jun Li1,2, Guoxian Deng3, Xianping Li3
1School of Physical Science and Technology, Guangxi University, Nanning, 530004, China.
Materials today. Bio
|September 25, 2024
概括
研究人员开发了一种无线,无电池的设备来管理膀收缩,为治疗下泌尿道功能障碍 (LUTD) 提供了更安全,更具成本效益的替代方案,并改善了患者的生活质量.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 下尿道功能障碍 (LUTD) 在生活质量和生理健康方面存在重大挑战.
- 目前针对LUTD的药物和行为疗法存在局限性.
- 现有的神经刺激器通常依赖于电池,这给长期植入和管理带来了挑战.
研究的目的:
- 开发一种创新的无线,无电池的设备,以加强膀收缩的管理.
- 为LUTD提供一个更安全,更具成本效益的替代方案,而不是目前的神经刺激装置.
主要方法:
- 设计并验证了一种紧的,完全可植入的,无电池的脉冲发生器,使用磁感应合器来提供无线电源.
- 该设备允许精确电刺激 (0-10V) 的肌肉或神经元.
- 能够实时无线调整刺激参数 (电压,持续时间,频率,脉冲宽度,间隔).
主要成果:
- 该设备通过刺激大骨盆 (MPG) 有效控制小鼠的膀收缩.
- 在小鼠中成功管理了双边尾神经切割的排尿.
- 这种植入装置的重量小于0.2g,体积小于0.1cm3.
结论:
- 开发的无线脉冲发生器为膀控制提供了一种新的电刺激方法.
- 与传统的电池驱动神经刺激器相比,这种技术提供了一个更安全,更具成本效益的解决方案.
- 预计将在未来的电刺激疗法中发挥关键作用,以消除功能障碍.
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