相关实验视频

Updated: Jun 12, 2025

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

揭示口腔菌群和结直肠癌之间的隐藏联系:双向的门德尔随机化分析和元分析

Zexin Zhang¹, Wenfeng Wu¹, Zhikai Xiahou²

¹The Second Clinical School of Guangzhou University of Chinese Medicine, Guangzhou, China.

Frontiers in microbiology

|September 25, 2024

概括

一些口腔细菌,包括Haemophilus和Fusobacterium,与结直肠癌 (CRC) 的发展有因果关系. 这项研究使用了门德尔的随机化来识别这些有助于CRC风险的特定口腔菌群.

科学领域:

微生物学微生物学
遗传学是一个遗传学.
在瘤学瘤学.

背景情况:

口腔微生物群对肠道环境和疾病的影响是公认的,但其在结直肠癌 (CRC) 发病过程中的具体作用尚不清楚.
研究口腔细菌和CRC之间的因果关系对于了解疾病机制和制定有针对性的干预措施至关重要.

研究的目的:

探索各种口腔植物与患结直肠癌 (CRC) 的风险之间的潜在因果关系.
使用可靠的统计方法识别可能导致CRC发展的特定口腔细菌.

主要方法:

采用双样本门德尔随机化 (TSMR) 分析来评估口腔植物对CRC的因果关系.
反变量加权 (IVW) 是主要方法,在独立队列和元分析中得到验证.
使用多变量门德尔随机化 (MVMR) 来调整潜在的混因素.

主要成果:

TSMR确定了17种可能与CRC相关的口腔植物,其中4种 (Haemophilus,Fusobacterium,Metamycoplasma salivarium,Mogibacterium pumilum) 在队列中得到了验证.
对三个队列的元分析证实了16个显著的关联.
MVMR分析强调了Capnocytophaga ochracea和Metamycoplasma salivarium在培训队列中具有重要意义,其他物种在测试队列中得到验证.

结论:

特定的口腔细菌,即Haemophilus,Fusobacterium,Metamycoplasma salivarium和Mogibacterium pumilum,表明与CRC发生和进展存在显著的因果关系.
这些发现强调了口腔微生物群在结直肠癌病因学的背景下的重要性.

关键词:

孟德尔的分析是孟德尔的分析.这种因果关系是因果关系.结肠直肠癌是什么意思这是一个元分析.口腔植物的口腔植物.这是唾液,唾液.舌头舌头舌头舌头

更多相关视频

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

相关概念视频

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...