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铁性碳素马尔托输液后严重的低酸盐血症:一个病例报告

N Arranz-Pasqual¹, A Torrent-Rodríguez¹, M T Miana-Mena¹

¹Pharmacy Service, Division of Medecines, Hospital Clínic de Barcelona, Barcelona, Catalunya, Spain.

Hospital pharmacy

|September 25, 2024

概括

铁碳酸 (FCM) 可以导致严重的低酸血症,这是一个严重的不良事件. 这一案例强调了需要监测接受FCM的患者,特别是那些有风险因素的患者.

科学领域:

临床医学临床医学
药理学药理学是指药理学的学科.
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

铁炭酸 (FCM) 是一种静脉注射的铁制剂,用于快速纠正缺铁.
虽然FCM通常是安全的,但与不良事件有关,特别是低酸血症.
FCM诱导的低酸血和相关风险因素的确切机制需要进一步阐明.

研究的目的:

在 Ferric carboxymaltose 给药后报告严重低酸性血症的临床病例.
强调在接受FCM治疗的患者中可能出现严重和持续的低酸血症.

主要方法:

一份病例报告详细介绍了一名男性患者,他因心脏切除术后的正常细胞贫血而接受了Ferric carboxymaltose治疗.
在FCM输液后监测血清酸盐水平和临床表现.

主要成果:

患者在FCM给药后发生了严重的低酸血症 (血清酸盐1.0 mg/dL).
这种情况需要住院治疗和长期补充 (16周).

结论:

铁碳酸可以导致严重和持续的低酸血症.
接受FCM的患者,特别是那些具有先前存在的危险因素的患者,需要对这种不良事件进行警监测.
需要进一步研究FCM诱导的低度血的机制和管理.

关键词:

药物不良反应药物不良反应药物不良反应报告/监测血液制品血液制品血液制品流体和电解质障碍流体和电解质障碍

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