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Updated: Jun 12, 2025

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
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通过相同的信号通路,LAIR-1和PECAM-1功能抑制GPVI介导的血小板激活

Christopher W Smith1, Zoltan Nagy2, Mitchell J Geer3

  • 1Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.

Research and practice in thrombosis and haemostasis
|September 25, 2024
PubMed
概括

白细胞相关免疫球蛋白类受体-1 (LAIR-1) 和血小板内皮细胞粘附分子-1 (PECAM-1) 通过相同的途径抑制血小板激活. 双重淘汰的小鼠显示血小板数量增加,但血栓形成正常,这表明它们有共同的调节作用.

关键词:
包含ITIM的接收器第一个层是LAIR-1.这就是PECAM-1的特点.血小板活动过度.血栓形成的原因是血栓形成.

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