黄素和认知功能:对黄素对有或没有神经认知障碍的成年人影响的系统审查
Aida J Francis1, Chithra Sreenivasan1, Aneri Parikh1
1Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Cureus
|September 25, 2024
概括
库尔库明补充剂在各种成年人群中有望改善工作记忆,尽管有潜在的胃肠道副作用. 需要进一步的研究来证实这些认知益处.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 认知能力下降和神经炎症是老年人群的重大健康问题.
- 黄中发现的黄是一种化合物,已表现出抗炎和抗氧化特性.
- 现有研究表明黄素可能具有神经保护作用,因此需要进行全面的审查.
研究的目的:
- 系统地审查黄素对神经认知结果的影响.
- 评估黄素对血清炎症生物标志物的影响.
- 综合了从18岁及以上的成年人身上进行的人类研究的证据.
主要方法:
- 在主要数据库 (PubMed,Science Direct,Google Scholar,Cochrane,MDPI) 进行系统的文献搜索.
- 基于PRISMA指南的1284项研究的选,使用与认知健康和黄素相关的关键词.
- 在20年内发表的12篇全文文章 (RCT,队列研究) 的选择,使用RoB2和纽卡斯尔-太华尺度进行评估.
主要成果:
- 黄素在不同成年人群中显著改善了工作记忆,包括那些有代谢,认知,情绪或化疗相关障碍的人.
- 在所有研究中,一致报告没有对炎症血清生物标志物的显著影响.
- 胃肠道副作用被认为是常见的不良事件.
结论:
- 黄素在多个成年人群中显示出对工作记忆的显著益处.
- 对炎症生物标志物的影响需要进一步研究.
- 由于人口特征变化和研究局限性,共享临床决策至关重要.
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