与 Clostridioides difficile 相关的肠道微生物和代谢特征 儿童感染复发
Xiaolu Li1, Fangfei Xiao1, Xufei Wang1
1Department of Gastroenterology, Hepatology and Nutrition, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Open forum infectious diseases
|September 25, 2024
概括
儿童中复发的Clostridioides difficile感染 (CDI) 与肠道微生物和代谢变化有关. 较低的微生物多样性和肠道中改变的胆酸可能预测CDI复发.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 儿童传染病 儿童传染病
背景情况:
- 由于发病率和治疗难度的增加,复发性困难菌感染 (CDI) 是一个重大的临床挑战.
- 识别与CDI复发相关的因素对于儿童群体的有效管理至关重要.
研究的目的:
- 调查与儿科CDI患者疾病复发相关的肠道微生物和代谢概况.
- 探索预测儿童CDI复发的潜在生物标志物.
主要方法:
- 预计将有84名儿童接受初级CDI.
- 使用16S rRNA基因测序和向代谢学分析便样本.
- 在初始诊断时分析细菌组成和代谢组.
主要成果:
- 31%的儿科CDI患者经历了复发.
- 复发性CDI病例显示肠道微生物的α多样性显著降低,β多样性明显明显.
- 短链脂肪酸 (SCFA) 生产细菌的丰富性减少和便SCFA水平的降低在复发的情况下被观察到.
- 在复发的患者中,发现了特定胆汁酸的较低水平,包括胆汁酸 (LCA).
结论:
- 肠道微生物群的变化,包括减少SCFA生产和修改的胆酸概况,可能会导致儿科CDI复发.
- 微生物和代谢物签名有可能预测儿童的CDI复发.
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