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通过抗肥胖药物调节的体重减轻和心血管结果
Yuchen Guo1, Chu Lin1, Xiaoling Cai1
1Department of Endocrinology and Metabolism, Peking University People's Hospital, No. 11, Xizhimen South Street, Xicheng District, Beijing 100044, P.R. China.
抗肥胖药物 (AOM) 显著降低心血管风险,包括心脏病发作和中风. 从AOM中减轻的每5公斤体重都与更好的心血管结果有关,这有利于这些药物的使用者.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 代谢疾病 代谢疾病
背景情况:
- 肥胖是心血管疾病的主要危险因素.
- 抗肥胖药物 (AOM) 的心血管效应需要彻底调查.
- 减肥通常与改善心血管健康有关.
研究的目的:
- 调查AOMs,减肥效应和心血管结果之间的关联.
- 量化与AOMs诱导的减肥相关的心血管益处.
- 为了比较AOM用户与安慰剂的心血管结果.
主要方法:
- 在PubMed,Embase,Cochrane和ClinicalTrials.gov的系统搜索到2024年4月.
- 包括129个随机对照试验 (RCT) 评估AOMs.
- 心血管事件的元分析,包括主要的不良心血管事件,心肌梗塞,中风和心力衰竭.
主要成果:
- 与安慰剂相比,从AOMs减轻5kg的体重与显著降低主要不良心血管事件 (RR 0.72),心肌梗塞 (RR 0.75),中风 (RR 0.60) 和心力衰竭 (RR 0.71) 的风险有关.
- 类似葡萄糖类1受体激动剂 (GLP-1RAs) 显示,每每5公斤体重减轻就有类似的心血管益处.
- 在各种AOM中观察到一致的心血管益处.
结论:
- 通过AOMs实现的减肥与显著的心血管益处密切相关.
- AOM提供了一种可行的策略,以减轻肥胖个体的心血管风险.
- 进一步的研究应该探索AOMs的长期心血管影响和具体机制.
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