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Updated: Jun 12, 2025

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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作为mRNA死亡化抑制剂的 Stapled

Sunit Pal1, Ilja Gordijenko1, Stefan Schmeing1

  • 1Chemical Genomics Centre, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.

Angewandte Chemie (International ed. in English)
|September 25, 2024
PubMed
概括

研究人员开发了一种新,NIP-2,通过向CCR4-NOT复合体来抑制信使RNA (mRNA) 降解. 这种方法稳定了有益的mRNA,为增加mRNA水平提供了新的治疗策略.

关键词:
RNA结合蛋白质是RNA结合的蛋白质.细胞透性 细胞透性已经死亡的enylation.稳定 mRNA 的稳定.带有的类聚合物

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