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药物耐药和药物敏感肺结核在儿童的胸部X射线比较
Saffanah Az Zuhriyyah1, Harry Galuh Nugraha2, Djatnika Setiabudi3
1Faculty of Medicine, Universitas Padjadjaran, West Java, Indonesia.
The clinical respiratory journal
|September 25, 2024
概括
胸部X射线发现在儿童中耐药结核病 (DR-TB) 和药物敏感结核病 (DS-TB) 之间存在差异. 巩固,纤维化和空腔在DR-TB中很常见,而在DS-TB中则更频繁地出现胸腔溢出.
科学领域:
- 儿科肺病学 儿科肺病学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 在儿童中,结核病 (TB) 诊断通常涉及胸部X射线 (CXR).
- 关于印尼儿科结核病CXR发现的研究有限.
- 在儿童中区分耐药结核病 (DR-TB) 和药物敏感结核病 (DS-TB) 对于有效的治疗至关重要.
研究的目的:
- 调查和比较患有肺性DR-TB和DS-TB的儿童的CXR发现.
- 识别潜在的放射性标记,有助于区分儿科结核病耐药性.
- 为印尼儿童结核病病例的评估和管理策略提供信息.
主要方法:
- 在2018年1月至2021年12月期间被诊断为肺DR-TB或DS-TB的儿科患者 (<18岁) 的回顾性分析.
- 从儿科呼吸学注册和结核病信息系统收集的数据.
- 患者特征,CXR发现和结核病严重程度的统计比较,使用千平方和费舍尔精确测试 (p<0.05).
主要成果:
- 分析了69名儿童 (31名DR-TB,38名DS-TB).
- 在DR-TB中常见的CXR发现包括巩固 (68%),纤维化 (42%) 和 (29%).
- 流是DS-TB中最常见的发现 (37%). 在50%的DR-TB病例中观察到严重的结核病 (p=0.008).
结论:
- 显著的CXR模式与儿童的DR-TB和DS-TB有关.
- 巩固,纤维化和腔腔表明DR-TB,而膜溢出更能表明DS-TB.
- 这些放射学差异可能有助于对儿科结核病的临床评估,因此需要进一步进行广泛的研究.
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