系统性炎症反应与代谢综合征之间的关系中的年龄差异
Haishan Wei1, Dan Xu1, Jiying Chen1
1Department of General Practice, Qilu Hospital of Shandong University, Jinan, 250012, China.
The Journal of clinical endocrinology and metabolism
|September 25, 2024
概括
系统性免疫炎症指数 (SII) 与18-65岁成年人的代谢综合征 (MetS) 有关. 这种炎症标志物预测了MetS发病率,但老年人的相关性不同.
科学领域:
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 系统性炎症越来越被认为是代谢综合征 (MetS) 的关键因素.
- 了解各种人群中炎症标志物和MetS之间的关系对于公共卫生至关重要.
- 目前的研究缺乏针对不同年龄人群的针对性建议,关于炎症和MetS.
研究的目的:
- 研究系统性免疫炎症指数 (SII) 和代谢综合征 (MetS) 之间的关联.
- 探索这种关联在不同成年年龄组之间如何变化.
- 为制定针对特定年龄的建议提供基础,以管理MetS风险.
主要方法:
- 利用了15959名成年人的数据 (2001-2018年NHANES),其中6739人被诊断为MetS.
- 通过将其分为四分位数,分析了全身免疫炎症指数 (SII).
- 采用了克鲁斯卡尔-瓦利斯,加权的奇方,多变量逻辑回归,子组,灵敏度分析和受限制的立方线.
主要成果:
- 在SII和MetS之间发现了显著的定量关联 (OR = 1.56,P < .001).
- 提升的SII独立地预测了MetS的所有五个组成部分.
- 这种关联在18-65岁的成年人中是显著的,但在老年人中没有;观察到一个反转的U形曲线.
结论:
- 系统性免疫炎症指数 (SII) 是年轻和中年成年人MetS的重要预测指标.
- 影响MetS的炎症机制的与年龄相关的差异需要进一步调查.
- 这些发现支持基于炎症概况和年龄的目标策略的开发,以预防MetS.
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