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铜纳米颗粒有效降低肉饮食和水中的沙门氏菌

Karine Patrin Pontin¹, Karen Apellanis Borges¹, Thales Quedi Furian¹

¹Centro de Diagnóstico e Pesquisa em Patologia Aviária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Avian pathology : journal of the W.V.P.A

|September 25, 2024

概括

在 brojler的料和水中的铜纳米粒子 (CuNP) 有效地减少了Salmonella Enteritidis. 补充CuNP并没有对肠道完整性,体重增加或有益细菌产生负面影响,显示出作为替代抗菌药物的前景.

科学领域:

动物科学动物科学
微生物学微生物学
纳米技术纳米技术

背景情况:

抗生素增长促进剂 (AGPs) 在家禽中广泛使用,但由于对抗菌素耐药性的担忧,它们的使用越来越受限制.
铜纳米颗粒 (CuNP) 正在被探索作为AGP的潜在替代品,提供抗菌性质,而不会导致耐药性.

研究的目的:

为了评估CuNP对肉料和水中的沙门氏菌肠杆菌的抗菌疗效.
评估CuNP补充剂对肉肠道完整性和整体健康的影响.

主要方法:

在水和模拟肠道消化能力模型中测试了CuNP对沙门氏菌的体外抗菌活性.
在体内研究涉及四组肉:对照,CuNP,恩拉米辛和CuNP + 恩拉米辛.
评估了肠道完整性,体重增加,乳酸细菌数量和铜含量.

主要成果:

与对照组相比,CuNP在体外水和料处理中显著降低了沙门氏菌肠杆菌的数量.
在补充CuNP的鸟类中,没有观察到对组织形态测量,体重增加或乳酸总细菌数量的显著不良影响.
肌肉和血液中的铜含量保持在正常范围内,这表明没有毒性.

结论:

在家禽料和水中,CuNP 显示出对 Salmonella Enteritidis 的显著抗菌活性.
对肉来说,CuNP补充是安全的,保持肠道完整性和正常生长参数.
CuNP显示出作为控制家禽生产中的沙门氏菌的可行,非抗生素替代品的潜力.

关键词:

抗微生物药物抗微生物药物沙门氏菌沙门氏菌沙门氏菌铜纳米颗粒是如何形成的在体外消化模型的消化性模型.肠道完整性肠道完整性补充补充补充补充补充

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