基于可控制的氧气释放-磁性高温疗法治疗的HCC中克服TACE后耐药性的研究
Jin-Xin Huang1, Wei-Hua Zhang1,2,3,4, Ye-Ming Wu1,2,3,4
1State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences & Medical Engineering, Southeast University, Nanjing, 210009, P. R. China.
新型氧气封装微球通过减少缺氧和增强化学栓塞疗效来对抗肝细胞癌 (HCC) 的耐药性,改善临床前模型中的生存率.
科学领域:
- 生物医学工程 生物医学工程
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
背景情况:
- 肝细胞癌 (HCC) 的治疗往往涉及药物排泄的珠子透气管动脉化学栓塞 (D-TACE).
- 瘤缺氧和TACE诱导的缺氧创造了一个双重的微环境,促进HCC的耐药性.
研究的目的:
- 开发新的氧气封装磁热药物释放微球 (OTD-Ms),以克服HCC中缺氧诱导的耐药性.
- 评估OTD-Ms在减少缺氧标记物和提高D-TACE治疗结果方面的有效性.
主要方法:
- 制造能够进行氧气封装和磁性高温的多重微球.
- 在体外和体内对OTD-Ms进行评估,以确定其降低低氧相关蛋白质 (HIF-1α,VEGF-A) 和药物耐药性标志物 (P-gp) 的能力.
- 在VX-2子瘤模型中使用OTD-Ms对D-TACE疗效和生存率的评估.
主要成果:
- OTD-Ms成功封装了氧气,并对磁热过热反应,增强了氧气的透性.
- 在体外和体内都观察到与缺氧相关的蛋白质 (HIF-1α,VEGF-A) 和P-糖蛋白 (P-gp) 的显著减少.
- 在子VX-2瘤模型中证明了D-TACE疗效的提高和生存率的提高.
结论:
- 多维他氧封装磁热药物释放微球 (OTD-Ms) 是对抗HCC中低氧驱动药物耐药性的有希望的策略.
- 在中期HCC治疗中,OTD-Ms有可能改善D-TACE的治疗结果.
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