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Updated: Jun 12, 2025

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
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在调节微处理器组件中,HIF-1α的转录独立作用

Jie-Ning Li1,2,3,4, Ming-Yang Wang5,6, Jhen-Wei Ruan1,2,4

  • 1Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Nucleic acids research
|September 25, 2024
PubMed
概括

低氧诱导因子1-α (HIF-1α) 通过与DGCR8结合来调节microRNA (miRNA) 的核成熟,抑制微处理器复合体组装和初级miRNA处理. 这揭示了核HIF-1α在miRNA生物发生中的非转录作用.

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