相关实验视频
Updated: Jun 12, 2025

08:28
Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
7.9K
G4LDB 3.0:一个用于发现和研究G-quadruplex和i-motif连接体的数据库
Qian-Fan Yang1, Xu-Rui Wang1, Yu-Huan Wang1
1Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, No. 29, Wangjiang Road, Chengdu 610064, China.
Nucleic acids research
|September 25, 2024
概括
现在G4连接物数据库 (G4LDB) 3.0提供了4800多个G-quadruplex/i-Motif连接物和51,000个活动条目. 这个增强资源为G4/iM研究提供了高级搜索,可视化和分析.
科学领域:
- 生物化学 生物化学
- 结构生物学 结构生物学
- 药用化学 医学化学
背景情况:
- 非正规的核酸结构,如G-四重复 (G4) 和i-Motifs (iM),具有独特的结构和生物特性.
- 这些结构是化学和生物应用中小分子开发的目标.
- G4联结体数据库 (G4LDB) 成立于2013年,旨在支持对G4向联结体的研究.
研究的目的:
- 推出G4LDB 3.0,这是G4联基数据库的升级版.
- 要突出新版本在内容和功能方面的广泛改进.
- 将G4LDB 3.0作为G4和IM研究的全面资源和研究工具.
主要方法:
- 数据库的更新包括了4800多个G4/iM配体和大约51,000个活动条目.
- 主要升级包括高级搜索功能,动态知识图和增强的数据可视化.
- 实现了一个新的动态分析功能,用于自动显示连接体结构集群和化学空间分布.
主要成果:
- G4LDB 3.0 显著扩展了其对G4/iM配体和相关活动数据的收集.
- 升级版提供了用于数据探索和分析的先进计算工具.
- 新功能促进了复杂数据的高效处理,并改善了用户体验.
结论:
- G4LDB 3.0代表了研究研究G-quadruplexes和i-Motifs.的研究人员在资源方面的实质性进步.
- 预计增强的数据库和分析工具将加速该领域的研究.
- G4LDB 3.0巩固了其作为G4/iM研究社区关键工具的作用.
相关概念视频
Ligand Binding Sites
12.8K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
12.8K
Globular and Fibrous Proteins
43.5K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
43.5K
G Protein-coupled Receptors
11.5K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
11.5K
Ligand Binding and Linkage
4.8K
Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked. In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
4.8K
Gene Families
8.8K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
8.8K
Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K

