瘤微环境衍生的外体:一种双刃剑,用于基于T细胞的先进免疫疗法
Ye Lu1, Jiarong Zheng2, Pei Lin1
1Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong 510280, China.
ACS nano
|September 25, 2024
概括
瘤微环境 (TME) 外体在癌症中具有双重作用,抑制免疫反应并提供治疗潜力. 了解TME中的外体功能是开发新型癌症治疗的关键.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 瘤微环境 (TME) 对癌症的进展和免疫规避至关重要.
- 外体,来自TME的细胞外囊泡,调解细胞间通信,并影响免疫反应.
- 这些囊泡转移蛋白质,脂质和核酸,影响瘤生长和转移.
研究的目的:
- 审查TME衍生的外体在癌症免疫学中的双重作用.
- 探索它们的免疫抑制功能和治疗潜力.
- 讨论TME内部的外体介导交叉通话及其对免疫治疗的影响.
主要方法:
- 对TME衍生外体的研究进行文献综述.
- 对外体载荷的分析,包括PD-L1.1等免疫调节分子.
- 检查TME内的外体介导细胞对细胞通信.
主要成果:
- TME外基因组通过抑制T细胞活动和促进免疫逃生来表现出免疫抑制功能.
- 外体可以携带免疫调节分子,有助于瘤的进展.
- 外体体还具有治疗潜力,可以作为抗原和共刺激信号的传递载体.
结论:
- 阐明TME外体机制对于推进癌症治疗至关重要.
- 向外体通路可以增强抗瘤免疫反应.
- 对外体介导相互作用的进一步研究将为新型免疫疗法的开发提供信息.
相关概念视频
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Tumor Immunotherapy
491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
Overview of Exosomes
2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K


