风险因素调查单边和双边慢性鼻炎与鼻息肉患者之间的不同结果
Jianwei Wang1,2,3, Yu Zhang2,3, Ying Chen2,3,4
1Qingdao Medical College, Qingdao University, Qingdao, China.
Clinical and translational allergy
|September 25, 2024
概括
带有鼻息肉的双边慢性鼻炎 (CRSwNP) 的结果比单边的CRSwNP. 喘,乙素和CT评分是双边病例中不良结果的关键风险因素,而血基素则表明单边病例的风险.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏和免疫学 过敏和免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 长期鼻炎与鼻息肉 (CRSwNP) 的研究主要集中在双边病例上,使单边的CRSwNP受到认可.
- 本研究通过比较单边和双边CRSwNP之间的临床特征,结果和风险因素来解决知识差距.
研究的目的:
- 描述单边与双边CRSwNP的独特临床特征和结果.
- 在每个CRSwNP亚组中确定与疾病控制不良相关的特定风险因素.
主要方法:
- 对310名单边CRSwNP患者和596名双边CRSwNP患者进行了比较分析.
- 评估包括人口统计数据,细胞分析 (组织和血液),内镜和CT成像得分,复发率和疾病控制状态.
- 采用多变量Cox比例危险模型来确定不良结果的风险因素.
主要成果:
- 双边CRSwNP患者呈现出更高的吸烟率,过敏性鼻炎 (AR),喘,组织异osinophils和血液炎症细胞.
- 在双边组中观察到更高的内镜聚得分,总CT得分和调整的CT得分,在单边组中观察到更高的调整的上腺得分是一个显著的例外.
- 双边CRSwNP与复发增加,不受控制的疾病和随访时更多的症状有关.
结论:
- 双边CRSwNP的特点是,与单边CRSwNP相比,疾病的严重程度更高,结果更差.
- 双边CRSwNP中不良结果的关键风险因素包括喘,组织乙素和CT总得分.
- 血基细胞作为一个显著的风险因素,特别是在单边的CRSwNP病例中出现了糟糕的结果.
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