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败血症引起的凝血病患者的温度和预后之间的非线性关系:来自MIMIC-IV数据库的回顾性队列研究
Guojun Chen1,2,3, Tianen Zhou1,2,3, Jingtao Xu1,2
1First People's Hospital of Foshan, Department of Emergency, Foshan, Guangdong, China.
The western journal of emergency medicine
|September 25, 2024
概括
败血症引起的凝血病患者的轻度发烧 (37.0-38.0°C) 与较低的死亡率有关. 温度低于36.0°C显著增加死亡风险,而更高的发烧显示出不太明显的趋势.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 败血症引起的凝血病 (SIC) 是败血症的严重并发症.
- 对于SIC患者体温的预后作用尚不清楚.
研究的目的:
- 为了研究体温与毒诱导的凝血病患者的死亡率之间的关联.
主要方法:
- 分析了来自9,860名SIC患者的数据.
- 根据前24小时的最高温度对患者进行分类.
- 多变量回归分析以确定温度与死亡率的关系和28天死亡率.
主要成果:
- 温度在37.0-38.0°C,38.0-39.0°C和≥39.0°C之间与28天死亡率的降低有关.
- 低于36.0°C的温度与明显更高的死亡率有关.
- 观察到温度和死亡率之间存在非线性关联,除了脑血管疾病外,没有影响的改变.
结论:
- 37.0-38.0°C的体温与SIC患者的较低死亡率相关.
- 温度超过38.0°C显示死亡风险增加的趋势.
- 需要进一步的研究来证实这些发现并探索潜在的机制,特别是在患有脑血管疾病的患者中.
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