肌痛性脑膜炎/慢性疲劳综合征和纤维肌痛患者的上腺功能障碍:系统性审查和元分析
Jolien Hendrix1,2,3, Lara Fanning2, Arne Wyns1,2
1Pain in Motion (PiM) international research group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Rehabilitation Sciences & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.
European journal of clinical investigation
|September 25, 2024
概括
这项研究发现肌痛性脑膜炎/慢性疲劳综合征 (ME/CFS) 的上腺功能障碍,上腺素升高和受体表达改变. 纤维肌痛 (FM) 患者表现出对运动的上腺素反应减弱,这表明了不同的病理生理机制.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 和纤维肌痛 (FM) 是复杂的疾病,具有重叠的症状和已知的自主功能障碍.
- 以前的研究集中在神经生理学方面,需要对交感功能障碍的生物标志物的审查.
研究的目的:
- 与健康对照人群相比,系统地审查和元分析ME/CFS和FM患者的生物上腺激素标记物.
- 阐明同情功能障碍和上腺功能异常在ME/CFS和FM病理生理学的作用.
主要方法:
- 在PubMed,Web of Science,Embase和Scopus数据库中进行系统搜索.
- 包括测量ME/CFS或FM患者与健康对照者的外周生物上腺体标志物的研究.
- 使用R统计软件对37项研究的数据进行的元分析.
主要成果:
- ME/CFS患者的休息上腺素和β1上腺素受体表达水平升高.
- ME/CFS患者在运动后表现出α2A和β2上腺素受体表达和COMT水平的增加,以及对静止测试的增强性诺亚上腺素反应.
- 纤维肌痛患者对运动的上腺素反应减少,没有显著的基线差异.
结论:
- 上腺功能障碍在ME/CFS中比在FM中更为突出.
- 在ME/CFS中,基线上腺素升高和非典型的运动反应突出显示上腺素异常是其病理生理学的关键贡献者.
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