与乳糖不耐症 (LI) 相关的肠道微生物组和血清代谢组变化:基于美国肠道项目 (AGP) 的病例控制研究和配对样本研究
Hong Xue1, Yitian Wang1, Chunfeng Mei1
1Digestive Laboratory of Traditional Chinese Medicine, Research Institute of Spleen and Stomach Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
mSystems
|September 25, 2024
概括
这项研究揭示了乳糖不耐症 (LI) 个体的肠道微生物组和代谢特征. 这些变化,包括特定的细菌物种和代谢物,影响炎症路径,并可能为LI预防和治疗提供点.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 乳糖不耐症 (LI) 是由于乳糖缺乏而引起的胃肠道疾病.
- 肠道微生物组在LI中的作用尚未完全理解.
- 有限的数据存在于LI患者的微生物群和代谢变化.
研究的目的:
- 为了研究乳糖不耐症中的元基因组和代谢学特征.
- 探索肠道微生物群和血清代谢物之间的相互作用.
- 为了确定潜在的基于微生物组的治疗点LI.
主要方法:
- 使用美国肠道项目 (AGP) 数据对对样本调查.
- 在中国队列中进行的元基因组和非向代谢组分析.
- 在老鼠身上进行便微生物群移植 (FMT) 实验.
主要成果:
- 在AGP数据中确定了14种不同的微生物属;7种物种和9种代谢物预测了中国队列中的LI.
- 在LI中观察到大肠杆菌的增加和Faecalibacterium prausnitzii/Eubacterium rectale的减少.
- FMT-LI大鼠表现出内脏过敏,改变了微生物群,并通过增加的促炎细胞因子丰富了MAPK信号.
结论:
- LI与肠道微生物和代谢特征的破坏有关.
- 特定的微生物和代谢变化与LI症状和炎症相关.
- 这些发现突出了基于微生物组的干预措施对LI的潜力.
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