饮食成分对辐射保护和辐射敏感性的影响:综合性审查
Md Monirul Islam1, Nahida Sultana1, Chang Liu2
1Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh.
Annals of medicine
|September 25, 2024
概括
像维生素和抗氧化剂这样的饮食化合物可以防止辐射损伤或增强癌症治疗的有效性. 了解这些影响可以改善辐射治疗,减少副作用.
科学领域:
- 营养科学 营养科学
- 辐射生物学 辐射生物学
- 分子瘤学分子瘤学
背景情况:
- 暴露于辐射会给健康带来风险,特别是在放射治疗和核事故中.
- 饮食成分提供潜在的辐射保护和辐射敏感作用.
研究的目的:
- 审查饮食成分对辐射敏感性的影响.
- 探索它们在癌症治疗中的辐射保护和辐射敏感化方面的潜力.
主要方法:
- 关于饮食成分 (维生素,矿物质,抗氧化剂,植物化学物质) 的研究文献综述.
- 对辐射保护和辐射敏感化的分子机制的分析.
- 检查饮食化合物调节的信号通路.
主要成果:
- 维生素C,E,和植物化学物质通过减少氧化应激和DNA损伤,显示出辐射保护潜力.
- 辐射保护器可以调节Keap1-Nrf2,NF-κB和PI3K/Akt/mTOR等通路.
- 饮食中的放射性敏感剂增强了瘤细胞中的DNA损伤和亡.
结论:
- 饮食干预可以调节辐射敏感性.
- 了解这些分子机制可以优化癌症治疗.
- 饮食策略可以提高放射治疗的疗效,并最大限度地减少副作用.
关键词:
饮食成分 饮食成分灭症 (apoptosis) 是一种死亡的过程.细胞存活率 细胞存活率辐射保护器 辐射保护器辐射敏感性 辐射敏感性无线电感应器 (Radiosensitizer) 是一种具有无线电感应力的装置.更多相关视频
05:39Author Spotlight: Radiotherapy and Clonogenic Assays for Advancing Cancer Research and Personalized Medicine
Published on: April 5, 2024
775
06:20Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
7.2K
相关概念视频
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Biological Effects of Radiation
15.3K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.3K
Radiological Investigation III: Pulmonary Angiogram and PET Scan
88
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
88
Mutations
34.8K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
34.8K
Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K
Isotopes and Radioisotopes
8.5K
In the early 1900s, English chemist Frederick Soddy realized that an element could have atoms with different masses that were chemically indistinguishable. These different types are called isotopes — atoms of the same element that differ in mass. Isotopes differ in mass because they have different numbers of neutrons but are chemically identical because they have the same number of protons. Soddy was awarded the Nobel Prize in Chemistry in 1921 for this discovery.
An isotope containing...
An isotope containing...
8.5K
