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新型piperidinyl thiazole衍生物的合成和抗真菌活性

Gajanan Shanbhag¹, Maruti Naik¹, Dnyaneshwar Wagh¹

¹Research & Development, PI Industries Ltd., Udaisagar Road, Madri Industrial Area, Udaipur, India.

Pest management science

|September 25, 2024

概括

研究人员开发了新型的piperidinyl thiazole杀菌剂,以对抗虫类疾病. 这些化合物在体外和体内表现出极好的活性,对抗像Phytophthora infestans这样的关键病原体,在现场试验中提供了有前途的疾病控制.

科学领域:

农业化学农业化学
有机化学有机化学
植物病理学植物病理学

背景情况:

研究新型虫虫杀菌剂对于作物保护至关重要.
皮皮里迪尼尔提亚醇杀菌剂代表了一类有前途的农业化学品.
生物异构体替代是一种有价值的策略,用于杀菌剂的发展.

研究的目的:

设计和合成新的piperidinyl thiazole类似物.
评估这些类型的杀菌活性对菌体病原体.
探索结构-活性关系,以优化杀菌剂的开发.

主要方法:

系统地探索piperidinyl thiazole修饰的方法.
在体外和体内查针对Phytophthora infestans,Plasmopara viticola,和Pseudoperonospora cubensis. 在体外和体内查.
结构-活动关系分析和化合物选择.

主要成果:

新型piperidinyl thiazole类似物在体外和体内表现出极好的杀菌活性.
含有O-链异环,双环皮佩里丁和硫胺替代的阿里尔的化合物显示出强烈的活性.
选择的化合物P14,P15和P25在低应用率下表现出优异的虫病现场控制.

结论:

生物异构体替代成功产生了具有强大的菌体控制的新型piperidinyl thiazole衍生物.
该研究确定了这种真菌杀菌剂类别的结构-活性关系.
开发的杀菌剂显示出在农业中控制虫虫病的商业潜力.

关键词:

植物虫感染了植物虫.血相对维蒂科拉 (Viticola) 的这种类型的虫子是 Pseudoperonospora cubensis.杀菌剂是一种杀菌剂.它们是oomycetes.皮佩里迪尼尔 thiazole 的使用情况.皮里多是一种.硫胺是一种硫胺.苏丹姆·苏尔塔姆 (苏丹姆·苏尔塔姆) 是一个

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