发育维生素D缺乏症和维生素D受体控制血液形成
Juhi Arora1, Nicole E Froelich1, Mengzhu Tang1
1Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA.
Journal of immunology (Baltimore, Md. : 1950)
|September 25, 2024
概括
母亲的维生素D缺乏影响胎儿免疫细胞发育和成人免疫反应. 在缺乏维生素D的小鼠中补充维生素D恢复了受体表达,并改善了对H1N1流感感染的抵抗力.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
背景情况:
- 维生素D状态,维生素D受体 (VDR) 和活跃的维生素D产生对于胎儿和成人血液形成至关重要.
- 了解免疫细胞中的VDR表达是解读维生素D在免疫中的作用的关键.
- 母亲的维生素D缺乏会影响后代的免疫发育和功能.
研究的目的:
- 研究维生素D和VDR在胎儿和产后免疫细胞发育中的作用.
- 确定母亲维生素D缺乏对免疫细胞VDR表达和对病毒感染的免疫反应的影响.
- 评估维生素D补充剂在减轻这些影响方面的治疗潜力.
主要方法:
- 使用转基因记者小鼠 (Vdr/tdTomato) 来追踪血液细胞中的VDR表达.
- 母亲诱导的维生素D缺乏 (D-) 或使用的VDR/Cyp27b1淘汰模型.
- 评估胎儿原始细胞种群,成人免疫细胞频率,VDR表达和对H1N1流感感染的易感性.
- 给缺乏维生素D的小鼠服用维生素D补充剂.
主要成果:
- 早在胚胎日15.5.5之前,在血液生成原始体中检测到VDR表达.
- 母亲的维生素D缺乏导致胎儿前代减少,成人免疫细胞 (T细胞,ILCs) 的VDR表达减少.
- 维生素D缺乏的母亲的后代对H1N1流感感染的敏感性增加.
- 维生素D补充恢复了VDR表达,并部分改善了对H1N1感染的抵抗力.
结论:
- 维生素D和VDR在胎儿和产后发育过程中调节血液形成.
- 发育性维生素D缺乏对成人免疫VDR表达有持久的影响,并损害抗病毒反应.
- 补充维生素D可以部分扭转这些缺陷,强调其对强大的免疫功能的重要性.
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