在老鼠中发现的SARS-CoV-2和其他冠状病毒,柏林,德国,2023,203年
Emerging infectious diseases
|September 25, 2024
概括
在柏林大鼠中检测到冠状病毒,其中一只表现出SARS-CoV-2抗体. 然而,阿尔法冠状病毒很普遍,这表明需要对动物进行监测,以了解冠状病毒传播和动物传播风险.
科学领域:
- 兽医病毒学 兽医病毒学
- 动物传染病研究研究
- 野生动物流行病学
背景情况:
- 冠状病毒是一种多样化的病毒群,具有重大公共卫生影响.
- 动物是众所周知的各种病原体的存储库,包括冠状病毒.
- 了解野生动物中的冠状病毒循环对于评估动物感染潜力至关重要.
研究的目的:
- 在柏林的老鼠群体中调查冠状病毒的存在和多样性.
- 为了确定SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 是否在城市老鼠中传播.
- 评估动物在冠状病毒流行病学中的作用.
主要方法:
- 在柏林捕获的130只野生老鼠的收集和测试.
- 对SARS-CoV-2抗体进行血清检测.
- 反转录PCR (RT-PCR) 用于检测冠状病毒RNA.
- 检测到的阿尔法冠状病毒的识别.
主要成果:
- 在130只大鼠中,在1只大鼠中检测到SARS-CoV-2抗体.
- 所有老鼠通过RT-PCR检测出SARS-CoV-2的阴性,表明没有活跃的血液循环.
- 在老鼠群体中发现了阿尔法冠状病毒.
- 这些发现表明,在这个城市老鼠群体中,SARS-CoV-2的传播有限或不存在.
结论:
- 虽然在这种老鼠群体中,SARS-CoV-2的暴露是最小的,但其他冠状病毒的存在凸显了它们作为潜在储库的作用.
- 对动物种群的持续监测对于跟踪冠状病毒的出现,传播动态和动物传染威胁至关重要.
- 需要进一步的研究来充分阐明城市生态系统中冠状病毒的One Health方面.
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