临床局部癌手术后瘤监测:UroCCR研究第129号
Alberto Martini1,2,3, Jean-Christophe Bernhard4,5, Ugo G Falagario6,7
1Department of Urology, La Croix du Sud Hospital, Quint Fonsegrives, France.
Minerva urology and nephrology
|September 25, 2024
概括
该研究验证了EAU指南的有效性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 2021年EAU指南引入了细胞癌 (RCC) 手术后的新后续计划.
- 该方案使用了三种风险类别系统,用于清晰细胞 (cc) 和非ccRCC.
- 目的是验证这个方案,并提供数据驱动的复发估计.
研究的目的:
- 验证新的EAU指导方针对细胞癌 (RCC) 的后续计划.
- 为清晰细胞 (cc) 和非ccRCC提供数据驱动的复发率估计.
- 确认或实施基于风险分层的瘤监测策略.
主要方法:
- 分析了来自法国28个中心的5320名患者的队列.
- 用Kaplan-Meier方法评估了低,中,高风险组的复发风险.
- 使用LOWESS平滑器图形调查了复发分布.
主要成果:
- 低风险的ccRCC,非ccRCC和中等风险的非ccRCC的复发风险约为10%.
- 在5年后,复发风险是:中等ccRCC 15%,中等非ccRCC 11%,高ccRCC 24%,高非ccRCC 8%.
- 与中等风险的ccRCC相比,高风险的非ccRCC与负面的3个月成像显示在复发中没有显著差异.
结论:
- 由于复发率低,中等风险的非ccRCC患者可能会遵循与低风险患者相似的监测策略.
- 高风险的非ccRCC患者有负面的3个月成像可能在这个时间点之后被跟踪类似于中等风险ccRCC患者.
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