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在大动脉切换手术后对大动脉转移的患者进行大动脉扩张的血液动力学分析,使用计算流体动力学

Woo Young Park¹, Sang Yun Lee², Jongmin Seo³

¹Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, Republic of Korea.

Journal of cardiovascular translational research

|September 25, 2024

概括

在大动脉完全转移的动脉切换手术后,新大动脉根扩张改变了大动脉的角度,并破坏了壁剪应力 (WSS) 模式,特别是在严重的情况下.

科学领域:

心血管外科心血管外科
医疗成像医学成像
生物医学工程生物医学工程

背景情况:

大动脉的完全转移 (TGA) 需要动脉开关操作 (ASO).
在ASO后,新动脉根扩张是已知的并发症.
新大动脉扩张的血液动力学影响仍然不完全理解.

研究的目的:

为了研究TGA的ASO后新大动脉根扩张的血液动力学影响.
分析不同扩张组中大动脉形几何和壁切应力 (WSS) 模式之间的关系.
评估计算流体动力学 (CFD) 在理解ASO后大动脉病理生理学方面的实用性.

主要方法:

对三组患者的分析:严重扩张,轻度扩张和正常的新动脉根.
利用基于心脏CT扫描的计算流体动力学 (CFD) 模拟.
量化了大动脉弧角和壁切应力 (WSS) 分布.

主要成果:

与正常组相比,在严重和轻度扩张组中观察到明显较小的大动脉弧角.
正常和轻度扩张组显示出一致的WSS模式,向大动脉弧曲线增加,然后减少.
严重扩张表现出破坏的WSS模式,由于循环再循环,远端上升性大动脉的值降低.

结论:

在TGA的ASO后的新大动脉根扩张与改变的大动脉弧形几何学有关.
严重扩张中破坏的WSS模式表明血液动力学发生了变化.
在ASO后的患者中,CFD是阐明大动脉扩张病理生理学的宝贵工具.

关键词:

大动脉根扩张动脉开关操作操作动脉开关操作计算流体动力学计算流体动力学大动脉的转移大动脉的转移旋转的旋转性旋转的旋转性墙壁剪切应力压力是什么

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