通过半理性设计,增强BpIH的伊马达酶活性,使其向3-异布基利化物转移

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Updated: May 5, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
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Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling

Published on: November 11, 2008

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Wenping Qin1,2, Long Xu3, Kun Cheng1

  • 1School of Pharmaceutical Sciences, Taizhou University, 1139 Shifu Rd, Taizhou, 318000, China.

Applied microbiology and biotechnology
|September 25, 2024
PubMed
概括

一种新的酶突变,YHS-I,显著增强了 (R) -3-异布基酸单胺 (R-IBM) 的产生,这是一种用于普雷加巴林合成的关键中间体. 这种工程造影酶实现了高的转换率和反体过量,改善了工业制药的制造.

关键词:
R-3-异布基酸单胺 (R-IBM) 的使用定向进化是指导进化的.伊米达斯 (Imidase) 是一种普雷加巴林是一种药物.半理性的设计设计.

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