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血造细胞移植后的味觉变化:一个范围审查
Caroline G R Dequae1, Judith E Raber-Durlacher1,2, Joel B Epstein3
1Department of Oral Medicine, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 HV, Amsterdam, The Netherlands.
概括
血造细胞移植 (HCT) 后常见的是失味症或味觉改变,在中性衰竭阶段达到顶峰. 味觉功能通常会在移植后恢复,这会影响患者的护理.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 造血细胞移植 (HCT) 是一种拯救生命的手术.
- 味觉的显著变化 - - 失味症 (dysgeusia) 可以影响患者在HCT期间和之后的生活质量.
研究的目的:
- 系统地审查接受高血压治疗的患者中异质症的流行率和特征.
- 了解整个HCT过程中的味道变化的时间模式.
主要方法:
- 在PubMed,Embase.com和Web of Science进行了全面的文献搜索,截至2023年6月22日.
- 包括的研究涉及前性评估的味觉知觉之前和之后的HCT在儿科和成人群体.
- 来自11篇选定的文章的数据进行了叙事综合.
主要成果:
- 在HCT之前,失音症的患病率很低,但在中性衰竭阶段达到顶峰,自我报告的患病率为20-100%,客观患病率为21.4%.
- 味觉功能在移植后的时期显示出恢复的趋势,自我报告的患病率下降到18%,客观率从0-33%.
- 所有基本的口味,包括,酸,甜和乌玛米,都受到影响,乌玛米和盐在治疗期间受到影响最大.
结论:
- 缺血症是HCT的一个显着的副作用,特别是在中性衰竭阶段.
- 植入后,口味变化通常会改善,尽管一些患者可能会经历持续的变化.
- 了解这些味道变化对于优化支持性护理和在HCT期间管理患者营养至关重要.
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