在原发性扩散性大B细胞淋巴瘤患者和复发性阻断性扩散性大B细胞淋巴瘤患者中,肠道微生物群发生显著变化
Yu Xu1, Chang Shi2, Jiejing Qian3
1Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, China. xuyu2007@zju.edu.cn.
概括
在扩散性大B细胞淋巴瘤 (DLBCL) 患者中,肠道细菌的组成不同. 特定的细菌变化与DLBCL发生和耐药性相关,表明潜在的新生物标志物.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群影响抗瘤免疫力和瘤微环境.
- 肠道微生物群在扩散性大B细胞淋巴瘤 (DLBCL) 中的作用及其耐药性在很大程度上是未知的.
研究的目的:
- 研究原发性DLBCL,复发性/耐药性DLBCL和健康个体之间的肠道微生物群的结构差异.
- 探索肠道微生物群组成与DLBCL发展和耐药性之间的潜在联系.
主要方法:
- 从26名初级DLBCL患者,28名RRDLBCL患者和30名健康对照患者收集了便样本.
- 用测序分析了肠道微生物群结构.
- 进行PICRUSt分析以预测功能基因含量.
主要成果:
- 在初级DLBCL患者中,fusobacteria得到了丰富.
- 在RR DLBCL群中,Fusobacterium的数量减少,Enterococcus的数量增加.
- 在RR DLBCL组中观察到细胞染色体P450相关基因的上调,可能导致药物耐药性.
结论:
- 在DLBCL患者中,肠道微生物群的组成发生了变化.
- 特定的细菌变异与DLBCL发生和耐药性有关.
- 细菌变化可以作为DLBCL的新生物标志物.
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