可持续的化碳点作为抗氧化剂和治疗货物的纳米载体
Afzal Hussain1, Mohamed Fahad Alajmi2, S Ganguly3
1Department of Pharmacognosy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh, 11451, Saudi Arabia. afihussain@ksu.edu.sa.
Journal of fluorescence
|September 25, 2024
概括
我们开发了酸盐和衍生碳点 (CLCD) 作为药物输送和强大的抗氧化剂的有希望的纳米载体. 这些CLCD表现出卓越的稳定性,生物相容性和显著的激素清除活性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 碳点 (CD) 添加异质原子提供光传感,药物传递和抗氧化特性.
- 酸盐和天然提取物是纳米材料合成的可持续前体.
研究的目的:
- 为了合成和描述基托和提取物 (CLCDs) 的碳点.
- 评估CLCD作为药物输送的纳米载体和抗氧化剂.
- 研究CLCDs的药物释放动力学和抗氧化疗效.
主要方法:
- 一步液热合成的CLCDs. 一步液热合成的CLCD.
- 使用FTIR,XPS,光,EPR和TEM进行表征.
- 在不同的pH条件下进行药物加载和释放研究.
- 使用DPPH,ABTS和基激素进行抗氧化活性评估.
主要成果:
- CLCDs表现出极好的体稳定性,抗氧化行为和细胞兼容性.
- 药物释放研究表明,在酸性条件下反应延迟,符合Korsmeyer-Peppas模型 (>95%的适合性) 与异常运输.
- 在1mg/mL的CLCD中,它对DPPH,ABTS和基基具有>85%的基因清除效果.
结论:
- CLCDs是有效的纳米载体,用于药物有效载荷的输送,具有显著的抗氧化特性.
- 低毒性和增强的药物输送能力使CLCD适合生物医学应用.
- 合成方法是高效的,产生稳定和功能性的纳米材料.
相关概念视频
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...