唾液蛋白调节Candida albicans的毒性,并可以预防口腔喉疹
Jose Alexandre da Rocha Curvelo1, Anna Lea Silva Barreto2, Brayan Leonardo Bayona-Pacheco3
1Divisão de Pesquisa clínica, Instituto Nacional do Câncer Marcelo Alencar, Rio de Janeiro, Brazil.
概括
唾液蛋白质海斯塔5和乳二烯降低了耐可纳的Candida albicans的活力和毒性. 这些发现表明,对于控制口腔角膜炎有潜在的治疗应用.
科学领域:
- 口腔微生物学 口腔微生物学
- 免疫学 免疫学 免疫学
- 抗微生物是一种抗微生物.
背景情况:
- 口腔候群病通常是由Candida albicans引起的,它具有毒性因子.
- 唾液免疫成分在 кандидоз发育中起作用.
- 抗可纳的抗菌株构成了治疗挑战.
研究的目的:
- 为了评估素5和乳二烯的抗真菌活性与可纳耐药的Candida albicans菌株.
- 评估它们对Candida albicans活力和毒性因素的影响.
主要方法:
- 在Candida albicans活力和细胞表面特性上测试 histatin 5 和 lactoferrin.
- 测量曼诺蛋白表达,蛋白质分解活性和上皮细胞协会.
- 分析酵母超结构,线粒体功能和膜透性的影响.
主要成果:
- 海斯5和乳酸降低了Candida albicans细胞活力.
- 海斯5增加了细胞表面的疏水性和降低了曼蛋白的表达.
- 立体素5增加了Candida albicans与上皮细胞的关联,但没有影响线粒体功能或膜透性.
结论:
- 在生理学度下,海斯5和乳酸会影响Candida albicans的活力和毒性.
- 保持这些蛋白质的唾液水平可以预防口腔喉疹.
- 外源的使用可能为耐药的Candida albicans菌株提供治疗策略.
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