间歇性禁食对女性生殖功能的影响:对动物和人类研究的回顾
Lei Mao1, Aixia Liu2, Xiaohui Zhang3
1Department of Women's Health, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Current nutrition reports
|September 25, 2024
概括
间歇性禁食有望改善PCOS和肥胖妇女的生育能力和月经调节. 然而,由于对母亲和婴儿健康的潜在风险,孕妇应该谨慎行事.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 代谢健康 代谢健康
- 时间生物学 时间生物学
背景情况:
- 间歇性禁食 (IF) 越来越受欢迎,但它对女性生殖健康的影响需要澄清.
- 现有的研究对IF在不同人群和禁食协议中的影响提出了不同的发现.
研究的目的:
- 审查各种FI疗法及其对女性生殖功能的影响.
- 探索将IF与生殖健康结果联系起来的潜在机制.
- 评估IF在不同女性群体的疗效和安全性,包括PCOS患者和怀孕期间.
主要方法:
- 对有关间歇性禁食和女性生殖健康的现有文献进行系统审查.
- 分析涉及不同IF协议的研究 (例如,交替禁食,时间限制的养,5:2饮食).
- 检查来自动物模型和人类研究的数据,包括超重/肥胖妇女,PCOS和孕妇.
主要成果:
- 交替禁食一天和8小时时间限制的食可能会对健康动物的生殖功能产生负面影响,但可以减轻高脂肪饮食的影响.
- 一个10小时的时间限制的食窗口改善了动物模型中的生育能力.
- 在患有超重/肥胖或PCOS的女性中,5:2饮食和时间限制的食改善了荷尔蒙特征和月经调节.
- 斋月禁食没有显示出与早产的强烈联系,但需要考虑母亲的体重和新生儿的结果.
- 关键的联系因素包括昼夜节律,肠道微生物群和代谢调节者.
结论:
- 间歇性禁食方案显示在肥胖和PCOS的妇女中治疗月经不规则和不孕不育的治疗潜力.
- 孕妇应该意识到与FI相关的潜在风险.
- 需要进一步的研究才能在这个不断发展的领域中得出最终的结论.
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