在美国人口中,有机酸盐阻燃代谢物的尿度
Yu-Song Huang1, Hui-Zhong Shi2, Xi Huang3
1Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
JAMA network open
|September 25, 2024
概括
2011-2020年间,美国儿童和成人尿液中有机酸盐阻燃剂 (OPFR) 代谢物度下降. 然而,暴露水平的差异仍然存在,特别是在基于父母教育的儿童中,这凸显了政策干预的必要性.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 有机酸盐阻燃剂 (OPFR) 是普遍存在的环境污染物,与不良健康结果有关,包括内分泌干扰,癌症和毒性.
- 了解OPFR代谢物暴露的时间趋势对于评估公共卫生风险至关重要,但这些数据仍然有限,特别是在不同年龄组.
研究的目的:
- 分析2011年至2020年期间美国儿童,青少年和成年人中关键OPFR代谢物 (BCEtP,BCPP,DPHP,DBuP) 的尿度的时间趋势.
- 调查社会人口统计学因素与这些时间暴露趋势的变化之间的关联.
主要方法:
- 一项基于人口的横截面研究,利用了来自美国四个国家健康和营养检查调查 (NHANES) 周期 (2011-2020) 的数据.
- 包括10,549名参与者 (6-19岁的儿童/青少年和20岁以上的成年人) 测量了尿路OPFR代谢物.
- 使用调查加权线性回归模型来估计趋势,并评估与社会人口统计学变量之间的关联.
主要成果:
- 在2011-2012年至2017-2020年期间,在儿童/青少年和成年人中观察到尿中二甲酸 (BCEtP) 的显著下降趋势 (P < .001).
- 在研究期间,尿中的二-1--2-) 酸盐 (BCPP) 度也在成年人中显著下降 (P = .002).
- 父母的教育程度与儿童和青少年的BCPP和BCEtP度有显著的关联,这表明持续的暴露差异.
结论:
- 过去十年来,美国人口的尿液OPFR代谢物水平有所下降,这表明监管或行为变化的潜在有效性.
- 持续存在的OPFR暴露的社会经济差异,特别是与儿童的家长教育有关,强调需要有针对性的公共卫生干预措施.
- 调查结果强调了在旨在减少环境污染物暴露和促进健康公平的政策中考虑社会经济因素的重要性.
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