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Updated: Jun 27, 2026

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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糖化产生拓上不同的α-Synuclein寡合菌株,并通过NLRP3-Inflammasome路径调节微质反应

Manisha Kumari1, Krishna Singh Bisht1, Kriti Ahuja2

  • 1Functional Proteomics Laboratory, Regional Centre for Biotechnology (RCB), NCR Biotech Science Cluster, Faridabad 121001, India.

ACS chemical neuroscience
|September 25, 2024
PubMed
概括

糖化会改变α-synuclein (α-synuclein) 的聚合,从而产生有毒的寡合体. 这些改性寡聚物触发了独特的微质免疫反应,影响神经炎症和神经元存活在synucleinopathies.

关键词:
含有NOD-LRR和pyrin域的蛋白3 (NLRP3) 的蛋白质.帕金森病是帕金森氏症的一种疾病.糖化α-同核素是一种糖性α-同核素.微质细胞中的微质细胞收费类感应器 2 类似收费类感应器α-synuclein 是一种同核蛋白.

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