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微质通过NF-κB信号传递从常见的空气污染物中引起代谢功能障碍

Lucas K Debarba¹, Hashan S M Jayarathne¹, Lukas Stilgenbauer¹

¹Department of Biological Sciences, Wayne State University, Detroit, MI.

|September 25, 2024

概括

空气中的暴露与胰岛素抵抗和2型糖尿病有关. 在男性中,微质NF-κB通路的激活驱动了代谢干扰,为疾病预防提供了新的目标.

科学领域:

环境健康环境健康
代谢疾病代谢疾病
神经免疫学神经免疫学

背景情况:

2型糖尿病 (T2D) 的患病率是一个全球性的健康问题.
空气污染物,如挥发性有机化合物 (VOC),在T2D中的作用是研究不足的.
是一种常见的空气中挥发性有机化合物,与T2D相关.

研究的目的:

对暴露和胰岛素抵抗进行第一个元分析.
研究将二烯暴露与小鼠代谢功能障碍相关联的机制.
确定微质信号在诱导的代谢障碍中的作用.

主要方法:

关于暴露和T2D的人类研究的元分析.
控制暴露,持续的葡萄糖监测和间接热量计在小鼠中.
微质细胞的RNA测序和小鼠的选择性基因剥离研究.

主要成果:

在暴露和胰岛素抵抗之间确立了强有力的关联.
在雄性小鼠中,二烯暴露破坏了能量平衡和下丘脑基因表达.
微质NF-κB通路激活被确定为素诱导的代谢功能障碍的关键调解者.
针对免疫细胞或受高血糖保护的微质细胞中的IKKβ的除.

结论:

素暴露与胰岛素耐药性和代谢障碍有关.
微质NF-κB通路对于调解化学诱导的代谢疾病至关重要.
这项研究揭示了一种病理生理机制,将空气中的毒素与代谢性疾病的发病联系起来.

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NF-κB-dependent Signaling Pathway

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
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