在癌症中SIRT1-介导的细胞免疫反应的参与
Nan Liu1, Jiafang Li2, Hui Dai3
1Department of Anesthesiology, the First Hospital of Jilin University, Changchun, Jilin 130021, China.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|September 25, 2024
概括
赛尔图因-1 (SIRT1) 影响癌症免疫力和进展. 向SIRT1提供了新的免疫疗法策略,以增强抗癌免疫反应并开发新的癌症治疗方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物化学 生化学
背景情况:
- 在全球范围内,癌症发病率和死亡率正在增加.
- 免疫疗法是癌症治疗的一个关键策略.
- 赛尔图因-1 (SIRT1) 是一种依赖NAD+的脱乙酶,参与癌症和免疫调节.
研究的目的:
- 审查SIRT1在各种免疫细胞中的作用.
- 阐明瘤进展中的SIRT1介导机制.
- 讨论在癌症免疫治疗中准SIRT1的治疗前景.
主要方法:
- 关于SIRT1研究的文献综述1.
- 分析SIRT1对免疫细胞的影响.
- 癌症中SIRT1信号通路的检查.
主要成果:
- SIRT1 影响各种免疫细胞功能.
- 通过多个信号通路,SIRT1在瘤进展中起着双重作用.
- 调节SIRT1活动会影响抗癌免疫力.
结论:
- SIRT1是瘤免疫微环境的关键调节者.
- 向SIRT1为癌症免疫疗法提供了一个有希望的治疗途径.
- SIRT1激活剂和抑制剂是潜在的抗瘤剂.
更多相关视频
相关概念视频
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
PI3K/mTOR/AKT Signaling Pathway
3.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.4K
The Intrinsic Apoptotic Pathway
6.4K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.4K
Tumor Immunotherapy
491
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
491
Cytotoxic T Cells-mediated Immune Response
858
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
858
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K


