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间接结构对精神分裂症的功能连接的影响,使用多重脑网络

Dandan Li¹, Yating Zhang¹, Luyao Lai¹

¹College of Computer Science and Technology (College of Data Science), Taiyuan University of Technology, Taiyuan, 030024, China.

Journal of psychiatric research

|September 25, 2024

概括

精神分裂症 (SZ) 患者由于间接的SC通路受损,结构和功能连接性 (SC-FC) 降低. 这项研究揭示了SZ中减少的调解效应,影响大脑通信.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
网络科学网络科学

背景情况:

精神分裂症 (SZ) 的异常功能连接 (FC) 与结构连接 (SC) 有关.
间接SC在SZ的FC中的作用仍然未被充分探索.
单层网络在分析间接SC-FC关系方面存在局限性.

研究的目的:

研究间接结构连接对精神分裂症功能连接的影响.
量化调解器和调解节点对SZ中间接SC的影响.
用多重网络方法分析SC-FC带宽和SZ患者的成本.

主要方法:

构建了一个多重结构连接功能连接 (SC-FC) 网络.
分析了SC-FC带宽和SC-FC成本,以评估间接的SC影响.
介绍并量化调解能力,调解成本,调解强度和调解成本.

主要成果:

精神分裂症患者的SC-FC带宽和SC-FC成本比健康对照人低.
在SZ患者中观察到受损的间接SC效应.
边缘和皮层下网络 (LSN),默认模式网络 (DMN) 和视觉网络 (VN) 都受到影响.

结论:

间接结构连接在精神分裂症中显著影响功能性沟通.
在SZ患者中减少的调解效应突出显示了大脑网络动态的改变.
这些发现为精神分裂症背后的生理机制提供了新的见解.

关键词:

在 DTI 中,DTI 是指DTI.功能性核磁共振 (MRI) 是一种功能性核磁共振.间接结构连接间接结构连接多个复杂网络的网络.精神分裂症是一种精神分裂症.

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