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疏水性氧化铁纳米颗粒:通过闪光纳米沉控制合成和相移

Sulalit Bandyopadhyay¹, Haroon Zafar¹, Muhammad Sarmad Khan¹

¹Particle Engineering Centre, Department of Chemical Engineering, Norwegian University of Science and Technology, NTNU, Trondheim, 7491, Norway.

Journal of colloid and interface science

|September 25, 2024

概括

研究人员开发了一种新方法来合成用于生物医学用途的氧化铁纳米粒子 (IONPs). 闪光纳米沉 (FNP) 能够实现精确的控制和水相转移,克服了这些多功能纳米材料的关键挑战.

科学领域:

纳米技术纳米技术
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

通过热分解合成的氧化铁纳米粒子 (IONPs) 为生物医学应用提供可调整的物理化学特性.
一个重大挑战是将疏水性IONP从有机溶剂转移到生物用途的水性环境.
传统的IONP合成和功能化的方法往往缺乏精确的控制和可扩展性.

研究的目的:

系统地研究合成条件对IONP属性的影响.
为IONP阶段转移和功能化开发一种可扩展和精确的方法.
评估功能化的IONP对潜在的生物医学应用的生物相容性.

主要方法:

IONPs是通过铁酸盐的热分解合成的,合成参数的系统变化 (油酸量,温度率,停留时间,溶剂).
闪光纳米沉 (FNP) 首次用于实现IONP的可扩展和大小控制的相移.
使用FNP对IONP施加了聚乳合甘油酸 (PLGA) 涂层,并分析了它们的特性 (水力动力直径,体稳定性,负载).

主要成果:

在合成过程中溶剂的选择显著影响了IONP大小 (10-30 nm) 和磁性 (75-42 Am2Kg-1).
FNP成功生产了单分散型,PLGA涂层IONP,具有控制的水力动力直径 (~250 nm),高合稳定性和高IONP负载 (高达43%).
合成和功能化的IONPs在人类皮肤纤维细胞中没有明显的细胞毒性.

结论:

合成条件,特别是溶剂,对生物医学应用的IONP特性进行了批判性控制.
闪光纳米沉是一种新,可扩展和精确的方法,用于疏水性IONPs的相移和功能化.
支持 FNP 的 IONP 显示出有前途的生物相容性和物理化学特性,可用于未来的生物医学翻译.

关键词:

封装封装是一种封装.闪光的纳米沉方式功能化的功能化.铁氧化物纳米粒子铁氧化物纳米粒子转移阶段转移阶段转移阶段转移聚合物涂层是一种聚合物涂层.热分解热分解

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