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Updated: Jun 12, 2025

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

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一种具有缺氧可切换光和光热效应的纳米光剂,用于缺氧成像指导的免疫抑制瘤微环境调制

Xudong Li¹, Xianbin Sun¹, Ya Wang¹

¹Cancer Metastasis Alert and Prevention Center, College of Chemistry, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China.

Journal of colloid and interface science

|September 25, 2024

概括

这项研究介绍了一种新的纳米激光系统 (CsBPNs),该系统针对缺氧瘤区域. CsBPNs可实现精确的光热和免疫疗法,有效地逆转免疫抑制瘤微环境,以改善癌症治疗.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症研究癌症研究

背景情况:

调节免疫抑制瘤免疫微环境 (TIME) 对于有效的癌症治疗至关重要.
缺氧瘤区域对传统治疗和免疫疗法构成重大挑战.
向瘤相关巨细胞 (TAMs) 是克服TIME介导免疫抑制的关键策略.

研究的目的:

开发一种对缺氧反应的纳米神经系统,用于成像和治疗固体瘤.
研究光热疗法和通过低氧向方法提供的免疫疗法的协同效应.
提高免疫治疗药物在缺氧瘤区域的输送和疗效.

主要方法:

使用二甲基 (BODIPY) 染料修饰的奇托制造一种对缺氧反应的两性药物载体 (CsB).
自组装的CsB与pexidartinib (PLX3397) 创建的CsBPNs纳米系统.
在3D瘤模型和动物研究中评估CsBPNs的特性,包括大小,稳定性,光和光热效应.

主要成果:

CsBPNs表现出均的大小,良好的稳定性,以及缺氧可切换的光和光热特性.
纳米载体促进了瘤组织的深度透和有效的缺氧成像.
在体外和体外研究表明,CsBPNs促进了TAMs再极化,逆转免疫抑制,并通过协同光热疗法增强了PLX3397的疗效.

结论:

开发的CsBPNs系统提供了一种新的策略,用于在低毒区检测和调节免疫抑制的时间.
这种针对缺氧的纳米疗法可以通过促进深度药物输送和协同治疗来实现精确的光免疫疗法.
这些发现有望在未来推进更有效,更有针对性的癌症免疫疗法.

关键词:

身体学身体学对低氧反应反应的低氧反应免疫治疗是一种免疫疗法.纳米其他anostics.光热疗法是一种光热疗法.

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