艾滋病毒感染者中不健康饮酒的综合步骤性酒精治疗与应急管理:一项随机对照试验
E Jennifer Edelman1,2,3, James Dziura4,5, Yanhong Deng4
1Department of Medicine, Program in Addiction Medicine, Yale School of Medicine, New Haven, CT.
Journal of acquired immune deficiency syndromes (1999)
|September 25, 2024
概括
综合阶段性酒精治疗与应急管理 (ISAT + CM) 适度改善了艾滋病毒感染者 (PWH) 不健康饮酒的3周禁酒. 为了更有效的干预,需要进一步的研究.
科学领域:
- 成 药物 药物 药物 药物
- 艾滋病毒/艾滋病研究研究
- 行为健康 行为健康
背景情况:
- 不健康的酒精使用在艾滋病毒感染者 (PWH) 中普遍存在.
- 需要有效的干预措施来促进这一群体的酒精戒断.
- 综合阶段性酒精治疗与应急管理 (ISAT + CM) 被评估.
研究的目的:
- 检查ISAT + CM对不健康饮酒的PWH中酒精戒断的影响.
- 为了比较ISAT + CM与通常的治疗 (TAU).
主要方法:
- 一个为期24周的多站点随机试验.
- 患有不健康酒精使用和酸乙醇水平>20 ng/mL的PWH被随机分配到ISAT + CM或TAU.
- ISAT + CM涉及社会工作者提供的CM和医生领导的激励增强疗法,如果没有达到戒断,则可以进入第二阶段.
主要成果:
- 120名PWH被注册;ISAT + CM组的87%进入了第二阶段.
- 在24周报告21天戒断的参与者比例在ISAT+CM组 (9%) 与TAU (0.3%) 相比,在ISAT+CM组更高.
- TAU优于ISAT + CM的后置概率为<0.0001.1,而后置概率为<0.0001.
结论:
- 在PWH中,ISAT + CM适度增加了自我报告的3周禁欲.
- 结果表明ISAT + CM在减少PWH的酒精使用方面可能发挥作用.
- 需要更有效的治疗方法来促进持续的戒断.
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