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一种气溶纳米复合微粒配方,使用里芬素-环德林合复合物治疗肺部疾病

Matthew T Freeman¹, Jie Shen², Samantha A Meenach³

¹University of Rhode Island, College of Engineering, Department of Chemical Engineering, Kingston, RI 02881, USA.

International journal of pharmaceutics

|September 25, 2024

概括

这项研究开发了一种可吸入的喷雾干燥配方的利芬素 (RIF),以改善结核病 (TB) 治疗. 新型纳米复合材料微粒提供直接的肺部输送,以提高疗效和患者的遵从性.

科学领域:

制药科学制药科学
药物输送系统药物输送系统
传染性疾病传染性疾病

背景情况:

结核病 (TB) 治疗依赖于利芬素 (RIF),但目前的口服疗法由于频繁的剂量导致患者遵守不良.
将RIF直接输送到肺部,在那里Mycobacterium结核菌居住在气管巨细胞中,可以增加药物度并减少全身副作用.

研究的目的:

开发和表征RIF的可吸入喷雾干燥配方,以改善结核病治疗.
创建一个纳米复合微粒 (nCmP) 配方,结合RIF-cyclodextrin (CD) 纳入复合物和RIF-loaded纳米粒子 (RIF NP) 进行控制释放.

主要方法:

合成和喷雾干燥的RIF-CD纳入复合物和RIF NP被合成成nCmP.
评估了气溶散射特性,包括颗粒大小和细颗粒分数.
评估了体外药物释放概况 (爆发和pH敏感) 和肺上皮细胞活力.

主要成果:

该RIF-CD nCmP配方表现出用于膜沉积的最佳气溶特性 (4.0μm,89%细颗粒分数).
该配方既显示了RIF-CD复合体的初始爆发释放,也显示了RIF NP持续的pH敏感释放.
该nCmP配方对肺上皮细胞无毒,而RIF NP显示有效的再分散.

结论:

RIF-CD nCmP配方提供了一个有效的策略,用于直接通过肺输送RIF.
这种新的配方使RIF能够立即和持续释放,从而有可能提高结核病治疗的疗效和患者的遵守性.

关键词:

气溶是一种气溶.循环德克斯林包含复杂的复合物纳米复合材料微粒的微粒里法皮辛 (Rifampicin) 是一种喷雾干燥喷雾干燥结核病是一种疾病.

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