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Updated: Jun 12, 2025

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

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通过索马托斯坦丁2A受体抑制脊柱GABAergic内神经元,TRPA1主动反应的患者有助于中央敏感化

Ramesh Pariyar1, Jigong Wang1, Regan Hammond1

  • 1Department of Neurobiology, The University of Texas Medical Branch, Galveston, Texas.

The journal of pain
|September 25, 2024
PubMed
概括

激活TRPA1的辅助剂通过激发体静止素内部神经元和通过SST2A-R抑制GABAergic内部神经元来驱动脊髓中央敏感性,从而导致疼痛过敏. 准SST2A-R可以治疗脑内可塑性疼痛.

关键词:
索马托斯塔丁,GABA能神经元,SST2A受体,鼻膜性疼痛,中心敏感化

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