累积平均感官障碍与认知功能和抑郁症状的关联:两项前性队列研究
Shuduo Zhou1, Zhisheng Liang2, Qi Li3
1Department of Biostatistics, Peking University First Hospital, No.8 Xi Shi Ku Road, Xicheng District, Beijing, China.
Journal of affective disorders
|September 25, 2024
概括
长期的视力和听力损失显著增加了老年人认知能力下降,痴呆和抑郁症的风险. 早期的感官护理干预对于保持认知健康和福祉至关重要.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 神经科学是一个神经科学.
背景情况:
- 感官障碍,包括视力和听力损失,影响全球数十亿人,造成重大公共卫生挑战.
- 这些损害对个人的生活质量和社会福祉有深远的影响.
研究的目的:
- 研究长期平均视觉,听觉和双感官障碍与认知障碍之间的独立关联.
- 检查感觉障碍与老年人痴呆和抑郁症状发生率之间的联系.
主要方法:
- 利用了来自健康与退休研究 (HRS) 和中国健康与退休纵向研究 (CHARLS) 的前性队列数据.
- 在随访期间使用曲线下的面积计算平均感官损伤.
- 采用考克斯回归模型,对共变量进行调整,以估计危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 每一个标准偏差 (SD) 增加的视力障碍与10-39%的认知障碍,痴呆和抑郁症的风险增加相关.
- 对于听力障碍和双重感官障碍也观察到类似的关联.
- 在视觉/双感官障碍和痴呆症风险之间确定了非线性剂量反应关系.
结论:
- 认知障碍,痴呆和抑郁症的诊断依赖于主观评估.
- 专注于感官护理的多层次策略对于改善老年人视觉和听觉功能至关重要.
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