银纳米颗粒的生物毒性因微/纳米塑料的共存而复杂
Lan Zhang1, Qian Li1, Shansen Ding1
1College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China.
概括
对银纳米粒子 (AgNP) 和塑料的同时暴露会加剧毒性,影响新陈代谢并引起炎症. 减少这种联合暴露对于食品安全和开发更安全的包装至关重要.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 银纳米粒子 (AgNP) 和聚乙烯 (PS) 塑料广泛用于食品包装和医疗应用.
- AgNP和PS塑料的组合毒理效应尚未得到充分理解.
- 对共同暴露的风险进行调查对于公共卫生和环境安全至关重要.
研究的目的:
- 在小鼠模型中评估AgNP和PS塑料的同时暴露的毒理学概况.
- 评估对肝毒性,神经毒性,炎症和肠道微生物群的影响.
- 了解塑料颗粒大小和剂量如何影响AgNP毒性.
主要方法:
- 通过90天的口腔 gavage,小鼠被管理AgNP和PS塑料.
- 进行生物化学分析以评估器官毒性和代谢变化.
- 描述了肠道微生物的组成和功能.
- 评估了神经毒性和炎症标志物.
主要成果:
- 同时暴露于AgNP和塑料显著加剧了AgNP的毒性.
- 能量和胆代谢发生了改变,不论塑料的类型或大小.
- 微塑料诱导细胞损伤,促进脂肪酸过氧化,并刺激炎症反应.
- 纳米塑料穿越了血脑屏障,可能导致神经元损伤和血管风险.
- 肠道微生物的变化是剂量依赖于微塑料暴露的.
结论:
- 塑料颗粒加剧了AgNP的毒性,影响了关键的代谢途径和免疫反应.
- 纳米塑料对神经系统和血管健康构成风险.
- 减少对AgNP和塑料的联合暴露对于食品安全至关重要.
- 建议开发可生物降解的包装材料以减轻这些风险.
相关概念视频
01:36Types of Toxins
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
01:26Toxic Reactions: Overview
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
01:24Microbial Corrosion
Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
01:28Microbial Bioremediation of Plastics
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...