在患有高尿血症的患者中,生命的基本8和心血管疾病:凯卢安队列研究
Yiran Xu1, Jingli Gao2, Jingdi Zhang1
1School of Public Health, North China University of Science and Technology, Tangshan, China.
Current problems in cardiology
|September 25, 2024
概括
一个高的生命必需品8 (LE8) 评分显著降低心血管疾病 (CVD) 风险在患有高尿路血症 (HUA) 的个体. 这种保护作用在年轻人和女性中最为明显,但在持续高尿酸水平的人中并非如此.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 一个高的生命必需品8 (LE8) 评分与癌症患者和年轻成年人的心血管疾病 (CVD) 风险降低有关.
- 在高尿血症 (HUA) 群体中,LE8和心血管疾病风险之间的关联仍然不清楚.
研究的目的:
- 研究生活必需品8 (LE8) 评分与高尿血症 (HUA) 患者心血管疾病 (CVD) 风险之间的关系.
主要方法:
- 在6814名HUA参与者的队列上使用了Cox回归模型进行主要分析.
- 第二次分析模拟了5,418名参与者的2006-2010年尿酸 (UA) 水平轨迹.
- 对不同人口分组的LE8得分进行了检查,对心血管疾病风险进行了评估.
主要成果:
- 随着LE8得分的增加,观察到心血管疾病风险的显著降低 (第2梯次HR:0.75,第3梯次HR:0.56).
- 较低的UA水平与心血管疾病风险降低有关 (低UAHR:0.49,中等UAHR:0.56),但在持续高的UA时没有看到这种情况.
- 性别和年龄影响了心血管疾病风险,观察到明显的差异.
结论:
- 较高的LE8分数与HUA人群中心血管疾病风险降低有关,特别是在年轻人和女性中.
- 在持久高尿酸水平的个体中,LE8的心脏保护性益处可能会降低.
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