夜间户外照明,空气污染和发生2型糖尿病的风险
Yonghao Wu1, Ye Jiao1, Peng Shen2
1Department of Public Health, and Department of Endocrinology of the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, China.
Environmental research
|September 25, 2024
概括
空气污染和夜间室外光线 (LAN) 与2型糖尿病 (T2D) 的风险增加有关. 兰和二氧化 (NO2) 之间的相互作用表明对T2D发病率的联合影响.
科学领域:
- 环境流行病学环境流行病学
- 公共卫生 公共卫生
- 内分泌学 在内分泌学.
背景情况:
- 空气污染和夜间室外光线 (LAN) 是2型糖尿病 (T2D) 的潜在环境风险因素.
- 这些暴露对T2D发病率的综合影响和相互作用仍然不清楚.
研究的目的:
- 调查室外LAN,颗粒物 (PM2.5,PM10) 和二氧化 (NO2) 与事件T2D的独立和互动关系.
- 探索空气污染物和LAN对T2D风险的潜在协同效应.
主要方法:
- 分析了在中国宁波 (2015-2018) 的24,147名参与者的队列.
- 土地利用回归和卫星数据估计了对PM2.5,PM10,NO2和室外LAN的暴露.
- 考克斯的比例危险模型评估了T2D发病率,检查了暴露之间的相互作用.
主要成果:
- 在108,908人年内,确定了1016例T2D病例.
- 增加T2D风险与更高的室外LAN,PM2.5,PM10和NO2.2水平有关.
- 在户外LAN和NO2之间发现了显著的乘法和加法相互作用.
结论:
- 空气污染和户外LAN都独立地与患T2D的风险增加有关.
- 户外LAN和NO2之间的相互作用表明,它们对T2D风险的综合影响可能大于它们单个影响的总和.
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