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Updated: Jun 12, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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通过主动和被动瘤向策略来强化向蛋白质降解:当前和未来的范围

Janarthanan Venkatesan1, Dhanashree Murugan2, Kalaiarasu Lakshminarayanan1

  • 1Department of Chemistry, School of Advanced Sciences (SAS), Vellore Institute of Technology (VIT), Vellore 632014, India; Drug Discovery Unit (DDU), Centre for Biomaterials, Cellular and Molecular Theranostics (CBCMT), Vellore Institute of Technology (VIT), Vellore 632014, India.

Pharmacology & therapeutics
|September 25, 2024
PubMed
概括

有针对性的蛋白质降解 (TPD) 提供了新的癌症疗法. 新的输送方法增强了PROTACs和相关降解剂的细胞特异作用,提高了安全性和有效性.

关键词:
基于Aptamer的PROTACs可以使用.降解剂抗体结合物 降解剂抗体结合物叶酸结合的PROTACs与叶酸结合基于纳米的 PROTACs.在PROTAC抗体结合体中这就是 PROTACs.有针对性的蛋白质降解.

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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs10:44

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