在人类-鸟类-环境接口的Enterobacter cloacae综合体中染色体位于blaCMH:一个健康视角
Jiewen Huang1, Nan Zhou2, Zile Cheng2
1Department of Laboratory Medicine, College of Health Science and Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Animal Health and Food Safety, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
The Science of the total environment
|September 25, 2024
概括
迁徙鸟类携带第三代抗素的Enterobacter cloacae (E. cloacae) 复杂菌株,包括与人类相关的类型. 基因组分析显示,宿主跳跃有助于全球抗菌素耐药性 (AMR) 基因的传播.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 菌 (E. cloacae) 综合体中抗菌素耐药性 (AMR) 是一个日益严重的公共卫生问题.
- 迁徙鸟类可以作为水库和传播耐药细菌的载体.
- 了解人类-鸟类-环境界面在抗药性耐药性传播中的作用至关重要.
研究的目的:
- 调查移徙鸟类的E.cloacae复杂菌株的抗菌素耐药性.
- 分析人类-鸟类-环境界面的耐药E.cloacae的遗传多样性和传播.
- 确定E.cloacae中的关键耐药基因及其进化史.
主要方法:
- 从迁徙鸟类标本中分离和识别E.cloacae复合体.
- 全基因组测序和生物信息分析E.cloacae分离物.
- 从全球来源对携带 blaCMH 的 E. cloacae 的遗传学分析.
主要成果:
- 从迁徙鸟类中分离出了11种第三代抗素的E.cloacae菌株.
- 人类相关的E. cloacae序列类型 (ST) 在候鸟中被检测到.
- blaCMH-4和blaCMH-6被确定为主要的耐药性基因;全球基因组分析显示中国,新加坡,尼日利亚和美国是关键国家.
- 遗传学分析表明宿主跳跃有助于现代耐药菌株的出现.
结论:
- 迁徙鸟类的息地是多药耐药的E. cloacae,在人类-鸟类-环境界面构成风险.
- 基因组数据揭示了AMR基因的进化途径和全球传播.
- 有效的监测和控制策略对于缓解耐药E.cloacae的传播至关重要.
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