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雷米马兰通过HMGB1-TLR4-NF-κB通路改善了经过深度低温循环停止后的术后认知功能障碍

Qi Mao¹, Beiwei Liang¹, Zhiwei Leng¹

¹Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Brain research bulletin

|September 25, 2024

概括

雷米马佐拉姆通过减少神经元损伤和炎症来保护深度低温循环停止 (DHCA) 后的认知衰退. 这种麻醉剂通过抑制HMGB1-TLR4-NF-κB通路而起作用,改善了老鼠的记忆和学习.

科学领域:

神经科学是一个神经科学.
麻醉学麻醉学
药理学药理学是指药理学的学科.

背景情况:

手术后认知功能障碍 (POCD) 是深度低温循环停止 (DHCA) 后的一个重大并发症.
在DHCA后的神经缺陷通常与全身炎症和脑缺血/再输损伤有关.
雷米马佐拉姆是一种麻醉剂,显示出对炎症状况和脑缺血的潜在保护作用.

研究的目的:

研究雷米马佐拉姆对DHCA诱导的神经元损伤的保护作用.
阐明雷米马佐拉姆在预防与DHCA相关的认知功能障碍方面作用的潜在机制.

主要方法:

在心肺绕道术期间,建立了一个DHCA的老鼠模型,在心肺绕道术期间使用不同的雷米马拉姆剂量.
用莫里斯水迷宫评估认知功能.
组织学分析 (H&E,TUNEL) 评估了海马损伤和亡;ELISA测量了炎症性细胞因子;西部斑块和免疫组织化学分析了蛋白质表达.

主要成果:

在DHCA大鼠中,雷米马佐拉姆的使用减少了组织损伤,神经元亡和微质激活.
该药物减少了炎症级联并降低了HMGB1-TLR4-NF-κB通路的调节.
雷米马佐拉姆在接受DHCA的老鼠中显著改善了记忆和学习能力.

结论:

雷米马佐拉姆有效地改善了在DHCA后的术后认知功能障碍.
保护机制涉及HMGB1-TLR4-NF-κB信号通路的调制.
这些发现强调了雷米马佐拉姆作为预防DHCA后认知障碍的潜在治疗剂.

关键词:

深度低温的循环停止,导致血液循环停止.在HMGB1-TLR4-NF-κB路径中.这是POCD的POCD.雷米马佐拉姆 (Remimazolam) 是一种药物.

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