疾病负担和患者特征与系统治疗利用与阿托皮性皮肤炎的成年人之间的疾病负担和患者特征:来自CorEvitas阿托皮性皮肤炎注册表的数据
Jonathan I Silverberg1, Linda Stein Gold2, Seemal Desai3
1Division of Dermatology, The George Washington University School of Medicine & Health Sciences, Washington, District of Columbia, USA.
The Journal of dermatological treatment
|September 25, 2024
概括
开始先进的系统性治疗阿托皮性皮炎 (AD) 的决定是复杂的. 许多患有严重AD的患者没有接受全身治疗,这表明疾病严重程度以外的因素会影响治疗的开始.
科学领域:
- 皮肤病学 皮肤病学
- 临床研究 临床研究
- 患者的治疗结果.
背景情况:
- 亚托匹性皮肤炎 (AD) 管理涉及关于先进的全身疗法的复杂决策.
- 了解影响系统治疗启动的因素对于优化患者护理至关重要.
研究的目的:
- 调查中度至重度亚托皮性皮肤炎患者的疾病负担和临床概况.
- 识别与启动新的全身疗法相关的患者特征.
主要方法:
- 来自前性,纵向性,非干预性CorEvitas AD注册表的数据分析.
- 在系统性和非系统性治疗组之间对人口统计,临床,并发症,疾病严重程度 (vIGA-AD,BSA,EASI,SCORAD) 和患者报告结果 (PRO) 的比较.
主要成果:
- 在883名患者中,673人开始了全身治疗. 非系统性组显示出意外高的严重疾病率 (vIGA-AD = 4: 39%),显著的BSA参与 (31%) 和高的EASI (19).
- 没有接受全身治疗的患者报告了对生活质量和疾病控制的严重负担.
- SCORAD,峰值,先前的生物使用和面部色与全身疗法启动有显著联系.
结论:
- 疾病负担是亚托皮性皮肤炎全身治疗启动的可能驱动因素.
- 显著的疾病负担患者中很大一部分没有接受全身治疗,这表明有其他影响因素.
- 需要进一步调查以阐明疾病严重程度以外的因素,这些因素会影响启动全身治疗的决定.
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